Effect of synthesis temperature on crystallinity, morphology and cell viability of nanostructured hydroxyapatite via wet chemical precipitation method: Effect of temperature on hydroxyapatite properties

Hydroxyapatite (HA) is the main natural mineral constituent of bones and is a good alternative for biomedical applications because it is osteoconductive, non-allergenic, and non-carcinogenic, which ensures high biocompatibility. A commonly used method for obtaining hydroxyapatite is the wet route, which is simple and low-cost, produces only water as a final residue, and provides HA with a crystallinity comparable to that of bone tissue, which favors its biocompatibility. Therefore, the objective of this work is to synthesize hydroxyapatite via the wet chemical precipitation method at different temperatures (4°C, 30°C, 50°C, or 70°C) to observe the influence of temperature on crystallinity, morphology, and cytotoxicity. The results of X-ray diffraction show that all syntheses resulted in pure hydroxyapatite, while increasing the temperature led to higher crystallinity (10.6% to 56.2%) and the crystal size was slightly affected. The increase in temperature changed the particle shape from irregular to needle-like. Cell viability was tested by PicoGreen® in VERO cells for samples at concentrations of 30 and 300µg/mL, and the samples synthesized at 4°C, with lower crystallinity, caused less DNA damage to cells compared to the negative control. &nbsp

Optimal Cross-Wind Towing and Power Generation with Tethered Kites

Non-powered flight vehicles such as kites can provide a means of transmitting wind energy from higher altitudes to the ground via tethers. Although there have been many proposals for systems to extract wind energy from higher altitudes, this paper focuses on the use of a light lifting body at the end of a tether to generate useful power. Two major configurations are studied: 1) the kite is used to tow a ground vehicle in the cross-wind direction, 2) the kite is flown to generate power using a ground generator. In both cases, the useful work done by the kite is transmitted to the ground through the tether. Both applications require automatic control of the kite. A simplified system model is used to study the nature of the optimal trajectories of the system for different wind speeds. Numerical results illustrate that optimal power generation requires complex three-dimensional kite trajectories, whereas cross-wind towing requires much simpler trajectories. A feedback tracking controller is demonstrated for tracking the kite trajectories in the presence of unsteady winds

A New Probability Distribution for SAR Image Modeling

This article introduces exponentiated transmuted-inverted beta (ET-IB) distribution, supported by a continuous positive real line, as a synthetic aperture radar (SAR) imagery descriptor. It is an extension of the inverted beta distribution, an important texture model for SAR imagery. The considered distribution extension approach increases the flexibility of the baseline distribution, and is a new probabilistic model useful in SAR image applications. Besides introducing the new model, the maximum likelihood method is discussed for parameter estimation. Numerical experiments are performed to validate the use of the ET-IB distribution as a SAR amplitude image descriptor. Finally, three measured SAR images referring to forest, ocean, and urban regions are considered, and the performance of the proposed distribution is compared to distributions usually considered in this field. The proposed distribution outperforms the competitor models for modeling SAR images in terms of some selected goodness-of-fit measures. The results show that the ET-IB distribution is suitable as a SAR descriptor and can be used to develop image-processing tools in remote sensing applications

Duvelisib: A 2018 Novel FDA-Approved Small Molecule Inhibiting Phosphoinositide 3-Kinases

Duvelisib (Copiktra®) is a dual inhibitor of phosphoinositide 3-kinases (PI3Kδ and PI3Kγ). In 2018, duvelisib was first approved by the Food and Drug Administration (FDA) for the treatment of adult patients with relapsed or refractory chronic lymphocytic leukaemia (CLL)/ small lymphocytic lymphoma (SLL) after at least two prior therapies. Duvelisib has also been approved under accelerated track for relapsed or refractory follicular lymphoma (FL) after at least two prior systemic therapies. In this review, we provide a series of information about duvelisib, such as the development of clinical trials for LLC/SLL and FL and the steps used for its synthesis

International energy assistance needs and options for the Democratic People's Republic of Korea (DPRK)

Recent agreements between the Democratic People's Republic of Korea (DPRK) and the other countries involved in the six-party talks on the future of the DPRK's nuclear weapons program have focused attention on the North Korean energy sector, and, specifically, what the international community can or should do to assist the DPRK in energy sector redevelopment. During two visits to North Korea in 1998 and 2000, a team of American and North Korean researchers conducted a unique rural energy use survey in a flood-affected rural village in the DPRK-the farming village of Unhari. The information gathered during the survey has important implications on how to properly approach the ongoing rural energy crisis in the DPRK, and, more broadly, to provide overall energy sector assistance. The results of the Unhari survey are described briefly, followed by suggestions of internal policy and legal reforms, approaches to international cooperation, key and attractive energy sector technologies and processes for energy sector redevelopment in the DPRK

Changes in mediobasal hypothalamic gonadotropin-releasing hormone messenger ribonucleic acid levels induced by mating or ovariectomy in a reflex ovulator, the ferret.

The ferret is a reflex-ovulating species in which receipt of an intromission induces a prolonged (+/- 12 h) preovulatory LH surge in the estrous female. This LH surge is probably stimulated by a large release of GnRH from the mediobasal hypothalamus (MBH). In Exp 1 we asked whether GnRH messenger RNA (mRNA) levels increase in response to mating so as to replenish the MBH GnRH stores needed to sustain the preovulatory LH surge. Estrous females were killed 0, 0.25, 0.5, 1, 3, 6, 14, or 24 h after the onset of a 10-min intromission from a male. Coronal brain sections ranging from the rostral preoptic area caudally to the posterior hypothalamus were processed for in situ hybridization using a 35S-labeled oligoprobe complementary to the human GnRH-coding region. We found no evidence of increased MBH GnRH mRNA levels during the ferret's mating-induced preovulatory LH surge. Instead, the number of GnRH mRNA-expressing cells dropped significantly in the arcuate region beginning 6 h after onset of intromission and remained low thereafter. Furthermore, cellular GnRH mRNA levels decreased in the arcuate region toward the end of the preovulatory LH surge. In Exp 2 we asked whether ovarian hormones regulate MBH GnRH mRNA levels in the female ferret. Ovariectomy of estrous females significantly reduced the number of GnRH mRNA-expressing cells in the arcuate region. This decrease was probably not due to the absence of circulating estradiol. Gonadally intact anestrous females had levels of MBH GnRH mRNA similar to those in estrous females even though plasma estradiol levels were equally low in anestrous females and ovariectomized females. Ovarian hormones other than estradiol may stimulate MBH GnRH mRNA levels in anestrous and estrous females